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Necrosis

from Parerga by Pillars Of Cacophony

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lyrics

Necrosis

Cells suffer necrosis
When exposed to extreme environmental stimuli
Adverse and excessive
When deleterious mutations encoded in the DNA
Result in ultra-structural and morphological features
Accompanied by extensive swelling of the cell
That contrasts sharply those
Undergoing apoptosis

Terminal
Irreversible
Absolute
The fate is sealed

A passive process not requiring synthesis
Minimal energy requirements
Not regulated by any homeostatic mechanism

The dominant concept
That has permeated
Stipulated that necrosis
Is merely the chaotic breakdown
Of a cell under intolerable conditions

Terminal
Irreversible
Absolute
The fate is sealed

Once triggered, it is inevitable

First, intracellular calcium increases
Next, calpains become activated
Finally, death

credits

from Parerga, released August 20, 2021

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Pillars Of Cacophony Graz, Austria

Science&Dissonance

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